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  • Tetracain-Hydrochlorid von Tetracain mit sicherer Lieferung mit sicherer Lieferung von höchster Qualität
    Procaine hydrochloride Biological Activity
    Description: Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3].
    Related Catalog:
    Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
    Signaling Pathways >> Neuronal Signaling >> GABA Receptor
    Research Areas >> Neurological Disease
    [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9.

    [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9.

    [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64.
  • Hochwertiges pharmazeutisches Zwischenpropanoylchlorid CAS 79-03-8
    Gebräuchlicher Name des Produkts: PropanoylchloridCAS Nr.: 79-03-8
    mit hoher Reinheit
  • 99% Reinheit CAS 20320-59-6 Lieferant neuer BMK-Glykidentulver
    Produktname: BMK -Pulver
    CAS NO: 20320-59-6


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